{"id":81,"date":"2020-12-08T10:57:02","date_gmt":"2020-12-08T10:57:02","guid":{"rendered":"https:\/\/www.sedapds.com\/?page_id=81"},"modified":"2023-04-12T15:41:31","modified_gmt":"2023-04-12T14:41:31","slug":"modelling-services","status":"publish","type":"page","link":"https:\/\/www.sedapds.com\/services\/modelling-services\/","title":{"rendered":"Modelling Services"},"content":{"rendered":"<p>Computer modelling and simulation is a method that can be used to predict and\/or confirm drug and formulation behaviour in vivo and facilitates the understanding of the exposure\/response relationship. Seda provide PK modelling services for the integration of data to mitigate the risks of drug properties impacting drug absorption and uncovers the relationship between dose, exposure and biological effect.<\/p>\n<h4><strong>Model-informed drug development helps solve the following challenges \/ questions:<\/strong><\/h4>\n<ul>\n<li>Dose selection<\/li>\n<li>Scaling and prediction of human pharmacokinetics<\/li>\n<li>What formulation type is required for clinical studies?<\/li>\n<li>Which formulations to use in preclinical studies?<\/li>\n<li>How does drug exposure relate to safety and efficacy?<\/li>\n<li>What are the best designs for preclinical and clinical studies to see activity?<\/li>\n<li>Which patients are most likely to respond?<\/li>\n<li>Representation of client companies in interactions with health agencies<\/li>\n<li>How do I translate my knowledge in one patient population to another population (e.g. adult to paediatric)?<\/li>\n<\/ul>\n<p>Modelling and simulation is used throughout development to guide and support longer term development strategy and clinical investment decisions. It puts emerging clinical data into context with preclinical and clinical data already available. Modelling and simulation can therefore build confidence in the development of your chosen compound\/formulation leading to reduced clinical testing and costs.<\/p>\n<p><a href=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2020\/12\/SEDA-Position-Paper-PBPK-Modelling-v4.pdf\" target=\"_blank\" rel=\"noopener\">PBPK modelling<\/a> is the combination of a set of known physiological parameters, in vitro ADME and invivo PK data, along with certain in silico values to create a dynamic model that describes the PK of a drug. This model can be used to understand and simulate PK in pre-clinical species and for first-in-human PK predictions. If PBPK models can be successfully be developed they have the potential to reduce the need for animal and human testing.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Computer modelling and simulation is a method that can be used to predict and\/or confirm drug and formulation behaviour in vivo and facilitates the understanding of the exposure\/response relationship. Seda provide PK modelling services for the integration of data to mitigate the risks of drug properties impacting drug absorption and uncovers the relationship between dose,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":82,"parent":61,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"templates\/service.php","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<meta name=\"description\" content=\"Seda&#039;s PK modelling services use computer modelling and simulation to analyse drug properties, to predict and confirm drug behaviour.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sedapds.com\/services\/modelling-services\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modelling Services | Seda\" \/>\n<meta property=\"og:description\" content=\"Seda&#039;s PK modelling services use computer modelling and simulation to analyse drug properties, to predict and confirm drug behaviour.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sedapds.com\/services\/modelling-services\/\" \/>\n<meta property=\"og:site_name\" content=\"Seda\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-12T14:41:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2020\/12\/shutterstock_1077270560-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1708\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@sedapds\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\">\n\t<meta name=\"twitter:data1\" content=\"1 minute\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.sedapds.com\/#website\",\"url\":\"https:\/\/www.sedapds.com\/\",\"name\":\"Seda\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/www.sedapds.com\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.sedapds.com\/services\/modelling-services\/#primaryimage\",\"inLanguage\":\"en-GB\",\"url\":\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2020\/12\/shutterstock_1077270560-scaled.jpg\",\"width\":2560,\"height\":1708,\"caption\":\"X-ray images of the human body being shown on a tablet computer\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sedapds.com\/services\/modelling-services\/#webpage\",\"url\":\"https:\/\/www.sedapds.com\/services\/modelling-services\/\",\"name\":\"Modelling Services | Seda\",\"isPartOf\":{\"@id\":\"https:\/\/www.sedapds.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.sedapds.com\/services\/modelling-services\/#primaryimage\"},\"datePublished\":\"2020-12-08T10:57:02+00:00\",\"dateModified\":\"2023-04-12T14:41:31+00:00\",\"description\":\"Seda's PK modelling services use computer modelling and simulation to analyse drug properties, to predict and confirm drug behaviour.\",\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.sedapds.com\/services\/modelling-services\/\"]}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/pages\/81"}],"collection":[{"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/comments?post=81"}],"version-history":[{"count":14,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/pages\/81\/revisions"}],"predecessor-version":[{"id":1872,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/pages\/81\/revisions\/1872"}],"up":[{"embeddable":true,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/pages\/61"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/media\/82"}],"wp:attachment":[{"href":"https:\/\/www.sedapds.com\/wp-json\/wp\/v2\/media?parent=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}