{"id":2150,"date":"2024-03-06T15:24:37","date_gmt":"2024-03-06T15:24:37","guid":{"rendered":"https:\/\/www.sedapds.com\/news\/"},"modified":"2024-03-06T15:57:21","modified_gmt":"2024-03-06T15:57:21","slug":"seda-collaborates-with-medicines-discovery-catapult-to-support-the-manufacture-and-characterisation-of-lipid-nanoparticles","status":"publish","type":"post","link":"https:\/\/www.sedapds.com\/news\/seda-collaborates-with-medicines-discovery-catapult-to-support-the-manufacture-and-characterisation-of-lipid-nanoparticles\/","title":{"rendered":"Seda collaborates with Medicines Discovery Catapult to support the manufacture and characterisation of lipid nanoparticles"},"content":{"rendered":"<p>Published in a new report, the collaboration between Seda and <a href=\"https:\/\/md.catapult.org.uk\/\">Medicines Discovery Catapult<\/a> (MDC) showcases the power of collective expertise in driving therapeutic innovation. This paper demonstrates the combined capabilities of Seda Pharmaceutical Development Services in the design, manufacture and physical characterisation of lipid nanoparticles for nucleic acid delivery, coupled with the advanced <em>in vitro<\/em> characterisation capabilities of MDC. Together, these organisations can support the design, prototype manufacture and screening of complex medicines ready for progression to preclinical <em>in vivo<\/em> testing and onwards to clinical development.<\/p>\n<div style=\"position: relative; padding-top: max(60%,326px); height: 0; width: 100%;\"><iframe style=\"position: absolute; border: none; width: 100%; height: 100%; left: 0; right: 0; top: 0; bottom: 0;\" src=\"https:\/\/e.issuu.com\/embed.html?d=preparation_characterisation_and_in_vitro_assessm&amp;hideIssuuLogo=true&amp;u=medicinesdiscovery\" sandbox=\"allow-top-navigation allow-top-navigation-by-user-activation allow-downloads allow-scripts allow-same-origin allow-popups allow-modals allow-popups-to-escape-sandbox allow-forms\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<p>Nucleic acid (NA)-based therapeutics hold immense promise in treating a wide range of diseases, from genetic disorders to infectious diseases and cancer. The interplay between formulation and biological performance is more complex in NA-based therapies compared to conventional small molecule drug development and demands a range of expertise and methods of analysis. This white paper is the result of a partnership between MDC and Seda with the primary aim of showcasing their respective but complementary laboratory capability in elucidating this formulation\/efficacy relationship.<\/p>\n<img loading=\"lazy\" class=\"aligncenter wp-image-2159 size-large\" src=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920-1024x512.jpg\" alt=\"nucleic acid delivered in lipid nanoparticles\" width=\"680\" height=\"340\" srcset=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920-1024x512.jpg 1024w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920-300x150.jpg 300w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920-768x384.jpg 768w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920-1536x768.jpg 1536w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2024\/03\/dna-g50a1e3819_1920.jpg 1920w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/>\n<p>&nbsp;<\/p>\n<p>In this study, siRNA-loaded liposomes (termed lipoplexes) and lipid nanoparticles (LNPs) were chosen as representative systems to investigate the influence of the manufacturing process of the lipid-based formulation on intracellular delivery. The design and manufacture, including process optimisation and physical characterisation, of both nanoparticle (NP) formulation types were performed by Seda. The biological performance of the NPs was assessed by MDC. Advanced microscopy techniques were used to demonstrate the kinetics of uptake, visualise intracellular trafficking and cytoplasmic delivery of siRNA by lipoplexes and LNPs.<\/p>\n<p>&nbsp;<\/p>\n<p>From a complex parenteral medicines perspective, Seda offers robust capability for supporting a range of advanced drug delivery technologies, including liposomes, dendrimers, polymeric nanoparticles, micelles, inorganic and LNPs, and is experienced in navigating challenges regarding formulation stability, characterisation, manufacturing (process understanding and scale-up), and the associated regulatory pathways for clinical trials approval and marketing authorisation.<\/p>\n<img loading=\"lazy\" class=\"aligncenter wp-image-1517 size-large\" src=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-1024x768.jpg\" alt=\"Malvern zetasizer for lipid nanoparticles\" width=\"680\" height=\"510\" srcset=\"https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-1024x768.jpg 1024w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-300x225.jpg 300w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-768x576.jpg 768w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-1536x1152.jpg 1536w, https:\/\/www.sedapds.com\/wp-content\/uploads\/2022\/08\/Zeta-2-2048x1536.jpg 2048w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/>\n<p>Partnering with us gives you access not only to our formulation design and manufacturing services but also to our network of internationally recognised collaborators for assessing the performance of nanoparticulate delivery systems.<\/p>\n<p>Medicines Discovery Catapult offers a comprehensive complex medicine analytical platform, incorporating <em>in vitro<\/em> characterization (cell-specific binding, uptake and cellular delivery), <em>in vivo<\/em> biodistribution and efficacy, and <em>ex vivo<\/em> tissue analysis to measure tissue accumulation, penetration and target engagement.<\/p>\n<p><a href=\"http:\/\/md.catapult.org.uk\/\">Medicines Discovery Catapult<\/a> (MDC) is an independent, not-for-profit innovation centre for drug discovery and part of the Catapult Network established by Innovate UK.<\/p>\n<p>Seda is a member of MDC\u2019s CRO Network and part of its <a href=\"https:\/\/md.catapult.org.uk\/our-capabilities\/virtual-rd\/\">Virtual R&amp;D<\/a> offering. <a href=\"https:\/\/md.catapult.org.uk\/partners\/seda\/\">Seda Pharmaceutical Development Services | Medicines Discovery Catapult<\/a><\/p>\n<p>Read more about the capabilities of the Seda consultants, modellers and laboratory scientists in the field of complex medicines here <a href=\"https:\/\/www.sedapds.com\/expertise\/complex-medicines\/\">Complex Medicines | Seda (sedapds.com)<\/a><\/p>\n<p>Contact <a href=\"mailto:claire.patterson@sedapds.com\">claire.patterson@sedapds.com<\/a> today to learn more about how Seda\u2019s Complex Medicines Services can propel your complex medicine development programme.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Published in a new report, the collaboration between Seda and Medicines Discovery Catapult (MDC) showcases the power of collective expertise in driving therapeutic innovation. This paper demonstrates the combined capabilities of Seda Pharmaceutical Development Services in the design, manufacture and physical characterisation of lipid nanoparticles for nucleic acid delivery, coupled with the advanced in vitro&#8230;<\/p>\n","protected":false},"author":2,"featured_media":2158,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[26,13],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<meta name=\"description\" content=\"Seda and MDC have collaborated to publish a new white paper on design and characterisation of lipid nanoparticles for nucleic acid delivery.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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