{"id":1073,"date":"2021-10-22T16:45:26","date_gmt":"2021-10-22T15:45:26","guid":{"rendered":"https:\/\/www.sedapds.com\/?p=1073"},"modified":"2022-09-21T11:23:29","modified_gmt":"2022-09-21T10:23:29","slug":"bionow-2021-oncology-conference","status":"publish","type":"post","link":"https:\/\/www.sedapds.com\/news\/bionow-2021-oncology-conference\/","title":{"rendered":"Bionow &#8211; 2021 Oncology Conference"},"content":{"rendered":"<p><span data-contrast=\"auto\">We are excited to announce that we\u00a0will be attending this\u00a0year&#8217;s\u00a0<\/span><a href=\"https:\/\/bionow.co.uk\/event\/BIONOW113\/2021-oncology-conference\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Bionow\u00a02021 Oncology Conference<\/span><\/a><span data-contrast=\"auto\">\u00a0at\u00a0Alderley\u00a0Park on Thursday 4<\/span><span data-contrast=\"auto\">th<\/span><span data-contrast=\"auto\"> November as gold exhibitors. Seda\u2019s Senior Principal Scientist, <\/span><a href=\"https:\/\/www.linkedin.com\/in\/claire-patterson-933027a1\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Claire\u00a0Patterson<\/span><\/a><span data-contrast=\"auto\">,\u00a0will be presenting\u00a0at the conference,\u00a0speaking about Bioavailability, Drug Delivery and Formulation, along with representatives from N4 Pharma and Quotient Biosciences.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>Some key messages from Claire&#8217;s presentation:<\/p>\n<ul>\n<li>The First step in formulation design is the target product profile (TPP) which brings together patient, disease, and molecule factors for optimal performance.<\/li>\n<li>Implicit in the TPP is selection of optimal route of administration<\/li>\n<li>Apply biopharma ceutics thinking \u2013 understand the physicochemical properties, administration site physiology and their interaction to achieve target in vivo performance profile.<\/li>\n<li>Understand the competing processes and use mathematical modelling to understand limitations and mitigations.\u00a0 This is a key Seda capability.<\/li>\n<li>Understanding the rate limiting step in absorption to enable selection of appropriate formulation mitigation strategy, e.g. amorphous solid dispersions for solubility limited absorption. Where other factors limit bioavilability e.g instability, low inherent permeability\/extensive efflux, extensive gut wall or hepatic first pass metabolism explore other options such as permeation enhancers or targeting ligands, or consider parenteral administration.<\/li>\n<li>There is an increasing trend towards subcutaneous delivery in oncology, particularly mAbs. Clear advantages over IV, not least the ability for the patients to self administer or at least require much less hospital\/ chair time than IV infusion.<\/li>\n<li>Mechanistic understanding of absorption rate and bioavailability is lagging behind that for oral, but significant progress is being made and Seda are linked in to communities driving these developments.<\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">The Bionow conference will also feature other insightful discussions and presentations including Early Detection\/New Approaches, Multiomics in Oncology Research, Role of Biobanks in Cancer Research &amp; Patient Care \u2013 Benchtop to Bedside, The Use of Wearables and AI to get Close to Patients and The Future of Cancer Therapy. Other keynote speakers at the event include Anke Bruning Richardson, University of Huddersfield and Kimberly Shepard, Lonza.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">As a gold exhibitor, we will also have a stand in the exhibition to promote our capabilities. Come and see us to find out more about our <a href=\"https:\/\/www.sedapds.com\/expertise\/complex-medicines\/\" target=\"_blank\" rel=\"noopener\">complex medicines<\/a> expertise <\/span><span data-contrast=\"auto\">and how we can provide value to your business.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are excited to announce that we\u00a0will be attending this\u00a0year&#8217;s\u00a0Bionow\u00a02021 Oncology Conference\u00a0at\u00a0Alderley\u00a0Park on Thursday 4th November as gold exhibitors. Seda\u2019s Senior Principal Scientist, Claire\u00a0Patterson,\u00a0will be presenting\u00a0at the conference,\u00a0speaking about Bioavailability, Drug Delivery and Formulation, along with representatives from N4 Pharma and Quotient Biosciences.\u00a0 Some key messages from Claire&#8217;s presentation: The First step in formulation design&#8230;<\/p>\n","protected":false},"author":2,"featured_media":451,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[15],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<meta name=\"description\" content=\"Seda are at the Bionow Oncology Conference 2021 as gold exhibitors. 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